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Glutathione

Glutathione

(Science: biochemistry) The tripeptide _ glutamylcysteinylglycine. It contains an unusual peptide Linkage between the _ carboxyl group of the glutamate side chain and the amine group of cysteine.

The concentration of glutathione in animal cells is _5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds.

glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leucotriene synthesis.


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cell specific markers

... readily expressed in human tissue. For example, the SNP rs2894804 from the SNP500Cancer database is located in a gene called GSTA1, coding for glutathione S-transferase. This enzyme functions in the detoxification of xenobiotics, including carcinogens, therapeutic drugs and environmental toxins. ...

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by MarkHolland
Sat Mar 30, 2013 3:16 pm
 
Forum: Cell Biology
Topic: cell specific markers
Replies: 3
Views: 6301

GST infused with PP2a

I have noooo idea about this, so does anybody have any clues as to why you would infuse GST (Glutathione S Transferase) with PP2a (Protein Phosphatase 2a)? In this context, we were using E coli in a lab setting and growing it... something to do with proteins. As I said, ...

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by Shorty
Tue Apr 10, 2012 7:39 am
 
Forum: Human Biology
Topic: GST infused with PP2a
Replies: 0
Views: 731

Why is 1 absorbance of proteins ~ 1 mg/ml?

... This is true for a heterogenic mixture of proteins, of course this will differ between different proteins. I just tested this with an enzyme (glutathione reductase in yeast) and if I did the calculation correct it differed less than 1 % of this value. I was hoping someone knows more about ...

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by poobear
Thu Feb 17, 2011 3:35 pm
 
Forum: Molecular Biology
Topic: Why is 1 absorbance of proteins ~ 1 mg/ml?
Replies: 1
Views: 4937

Human aging

... commonly present inside our cells has a high oxidative property and they are also responsible for the formation of hydroxyl radicals. Enzyme like glutathione peroxidase must act on these radicals to prevent the harmful effect to the cells. Nowadays, glutatathione-containing soaps are were widely ...

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by mcar
Fri Jan 09, 2009 9:59 am
 
Forum: Genetics
Topic: Human aging
Replies: 20
Views: 18951

Phytochelatin Synthase and chelation

Phytochelatins are oligomers of Glutathione, so yes they consist of just Glycine, glutamic acid and cysteine. Most organisms in general do not utilize heavy metals, infact they are quiet toxic especially to humans and plants. Plants chelate ...

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by vietknight
Tue Dec 02, 2008 1:37 am
 
Forum: Botany Discussion
Topic: Phytochelatin Synthase and chelation
Replies: 2
Views: 3604
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