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Genetic penetrance



(genetics) The frequency or rate of occurrence, typically in percentage, of a particular trait or condition (e.g. disease) expressed among individuals carrying the same deleterious (or disease-causing) gene.


Genetic penetrance describes the likelihood that a particular gene will be expressed and result in a disease.

It may be:

‘’Compare:’’ expressitivity

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Re: Multiple Sclerosis symptoms explained in terms of Penetrance

Multiple Sclerosis is not proven to be a genetic disorder. It does show signs of genetic linkage to some degree. This degree of linkage is it's relation to Penetrance and Expressivity. Hutington's disease, for example is a disease that is not considered ...

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by Fiorellas
Tue Jul 26, 2011 4:34 pm
Forum: Genetics
Topic: Multiple Sclerosis symptoms explained in terms of Penetrance
Replies: 3
Views: 6277

Reduced penetrance vs. multifactorial?

... to distinguish between a disease caused by a single-gene trait with low penetrance and a multifactorial trait? Let's say you were presented with ... would have implications for the calculation of recurrence risks and for genetic councelling? Any help in clarifying this issue for me would be greatly ...

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by Grumbot
Mon Apr 04, 2011 4:23 pm
Forum: Genetics
Topic: Reduced penetrance vs. multifactorial?
Replies: 1
Views: 3055

Genotype-Phenotype Correlations

... the use of single-nucleotide polymorphisms (SNPs) as markers in genetic linkage studies (1, 2). These markers can be used to identify loci ... led to the conclusion that EH is a multifactorial disease of delayed penetrance, with a substantial environmental influence. One gene system that ...

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by conecticut
Mon Aug 01, 2005 1:42 pm
Forum: Genetics
Topic: Genotype-Phenotype Correlations
Replies: 1
Views: 5385

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