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Dictionary » G » Gene duplication

Gene duplication

Definition

noun

A portion of the genetic material is duplicated or replicated resulting in multiple copies of that region.


Supplement

Gene duplication may lead to mutation and certain disorders. For instance, duplications of oncogenes cause many types of cancer, such as in the case of P70-S6 Kinase 1 amplification and breast cancer.

Gene duplication is also an important event in terms of evolution. Through duplication, many copies of genes in the genome can be produced. This would allow each gene to evolve independently to possess distinct functions. Such a set of evolutionarily related genes can be referred to as gene family.


Synonyms:


Compare: deletion mutation.
See also: mutation


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question

If you have two versions of the same gene, there may be less selective pressure to maintain the function of one copy, allowing ... retains the activity must bear the burden of selective pressure, as before the duplication event, while the now transformed copy is free(er) to develop in some new ...

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by blcr11
Thu Sep 04, 2008 3:00 pm
 
Forum: Genetics
Topic: question
Replies: 1
Views: 609

question

What leads to divergence besides formation of mutations? Do genes duplicate individually? if so, how? "Interestingly, Duplicate pairs ... to share cis motif structure than duplicate pairs from ancient genome duplication. For some gene families, there may be less selective constraint ...

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by youknowwho1
Tue Sep 02, 2008 3:12 am
 
Forum: Genetics
Topic: question
Replies: 1
Views: 609

Re: genes proteins

so why does whole genome duplication or gene duplication lead to transcription factor duplication?

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by youknowwho1
Mon Aug 25, 2008 8:20 am
 
Forum: Genetics
Topic: genes proteins
Replies: 5
Views: 782

Re: Morpholino review: how to knockdown

... mentioned (rescue through coinjection with a construct containing the gene's coding region in its native regulatory context, e.g. a BAC) and it ... whether this is a more common problem in vertebrates due to gene duplication because I have seen no evidence of it in sea urchin. If you weren't ...

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by snowcapk
Fri Aug 01, 2008 7:36 pm
 
Forum: Molecular Biology
Topic: Morpholino review: how to knockdown
Replies: 7
Views: 1739

Difference b/n cdc5 and cdk5

Unless there is a duplication of names--which is entirely possible--both CDC5 and CDK5 are kinases. The CDC names derive from Leland Hartwell's studies on the genetics of the yeast cell cycle and is short for cell-division cycle. CDC5 is an S. pombe gene; ...

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by blcr11
Wed Jul 18, 2007 2:22 pm
 
Forum: Molecular Biology
Topic: Difference b/n cdc5 and cdk5
Replies: 3
Views: 569
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