Gene amplification

Definition

noun

The process of duplicating a particular gene, causing the gene to increase in frequency inside the cell, as well as amplifying the phenotype (e.g. the proteins) that the gene confers (or code for).


Supplement

Gene amplification is one way by which a gene can be over-expressed. It is also linked to drug resistance in cancer cells where amplification results in cells being prevented from absorbing the chemotherapeutic drug.

Gene amplification may also occur artificially, as in by polymerase chain reaction technique.


Synonym: gene duplication.


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