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Gak cyclin g-associated kinase

GAK, cyclin G-associated kinase

(Science: chemical) Has a ser/thr protein kinase-like catalytic domain at the n-terminal; contains a tensin/auxilin-like domain; genbank d38560

Synonym: gak protein


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What are 5 target proteins for activated CDKs

aptitude: I think cyclins activate CDK, AKA cyclin dependent kinase

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by JackBean
Thu Nov 03, 2011 8:17 am
 
Forum: Cell Biology
Topic: What are 5 target proteins for activated CDKs
Replies: 2
Views: 1217

Re: Tissue cells and cancers.

... than others, but whether this is because their 'natural' cell cycling time is faster (and therefore, as you surmise, the mutated/cancer ... eg, RB protein phosphoryalated by CDK - cyclin dependent kinase), then the cell has no means to stop damaged DNA from replicating ...

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by Julie5
Tue Sep 21, 2010 9:21 am
 
Forum: General Discussion
Topic: Tissue cells and cancers.
Replies: 4
Views: 9445

cdc25 and tyrosin-15

... a phosphatase which dephosphorylates the tyrosine 15 residue of the cyclin-dependent kinase (Cdk). Dephosphorylation of tyrosine-15 of Cdk activates its kinase activity. You introduced ...

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by jb0378
Wed Jul 29, 2009 10:18 pm
 
Forum: Cell Biology
Topic: cdc25 and tyrosin-15
Replies: 1
Views: 2577

Difference b/n cdc5 and cdk5

... of names--which is entirely possible--both CDC5 and CDK5 are kinases. The CDC names derive from Leland Hartwell's studies on the genetics ... are related to polo-like kinases. CDK, on the other hand, is short for cyclin-dependent kinase. CDK5 is one of many kinases regulated via complex ...

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by blcr11
Wed Jul 18, 2007 2:22 pm
 
Forum: Molecular Biology
Topic: Difference b/n cdc5 and cdk5
Replies: 3
Views: 1398

Recent Nature papers

... Cheng, DiPinho, Sharpless, Scadden. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006:443, pp421-426. (Can't get the INK4a to be superscripted; ...

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by G-Do
Mon Oct 09, 2006 3:14 pm
 
Forum: Genetics
Topic: Stem Cells & Telemore lengths & Mitochondrial DNA
Replies: 3
Views: 2446
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