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Fusion proteins bcr-abl

Fusion proteins, bcr-abl

translation products of a fusion mrna derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukaemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukaemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in abelson murine leukaemia virus.


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... repair before division; simultaneously, ATM and ATR activate DNA-repair proteins to attempt DNA repair (DNA-Damange- Response np). When the cell ... as double stranded breaks (DBS) which tiggers chromosomal break-fusion-bridge cycles that result in the formation of new telomeres (from ...

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... not cause like short indels, changes in bases etc. But they can cause fusion proteins due to fused chromosome parts. There are some well known examples involved in cancer.

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