Dictionary » F » Fragility test

Fragility test

Fragility test

a test that measures the resistance of erythrocytes to haemolysis in hypotonic saline solutions; erythrocytes to be tested are added to varying concentrations of saline (usually ranging from 0.85 to 0.10% sodium chloride with 0.05% increments), and beginning and complete haemolysis are measured; normal erythrocytes show initial haemolysis at concentrations of 0.45 to 0.39% and complete haemolysis at 0.33 to 0.30%; in hereditary spherocytosis the fragility of the erythrocytes is markedly increased, whereas in thalassaemia, sickle cell anaemia, and obstructive jaundice the fragility of the erythrocytes is usually reduced.

Synonym: erythrocyte fragility test.


Please contribute to this project, if you have more information about this term feel free to edit this page



This page was last modified 21:16, 3 October 2005. This page has been accessed 2,553 times. 
What links here | Related changes | Permanent link