Founders

... terms, it's how population size and composition can affect genetic drift. If there is a small population, whether they were separated, or it's a founders effect thing OR a bottleneck event occurred, that population is subject to more wholesome changes because there are only a few members; the ...

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... but have only just come to appreciate in answering this question, is that these retroelements (themselves derived from retroviruses and/or the founders of retroviruses) jumped in to the genome, and interuppted the genes. The cells which survived had to learn to unsplice these viruses, but rather ...

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... for the PCR (e.g. actin?). Although I may be wrong on this next point, my suspicion from what you tell me is that your PCR failed but that your founders are genuine- the big question though is whether your founders have transgenic gonads - it is possible that they are mosaic - and the transgene ...

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... transgenic mice with that specific DNA piece. Out of about 45 mice that I genotyped, only about 3 mice gave me the right bands (so I have 3 founders), indicating the presence of the foreign DNA in the mouse. I got few pups from these founders that have the foreign DNA as well. However, few ...

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... better (by chance or not) during the population reduction. It is very similar to the "founder effect", but with a wider application (founders are just a particular case)

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