Fluoroquinolone

Fluoroquinolone

(Science: pharmacology) a new class of antibiotics with a broad spectrum of activity. They are well-absorbed orally, with good tissue penetration and relatively long duration of effect. These agents bind to dna and impair its replication.

They are synthetic antimicrobial agents with the characteristic 4-quinolone ring structure and containing a fluorine moiety at the 6-position. Some members also have a 1-piperazinyl group at the 7-position. Fluoroquinolone agents have greater intrinsic antibacterial activity and a broader antibacterial spectrum than the quinolone agents.

Examples include: ciprofloxacin, norfloxacin, cinoxacin, lomefloxacin, enoxacin and ofloxacin.

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