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Fibronectin

Fibronectin

(Science: protein) glycoprotein of high molecular weight (2 chains each of 250 kd linked by disulphide bonds) that occurs in insoluble fibrillar form in extracellular matrix of animal tissues and soluble in plasma, the latter previously known as cold insoluble globulin. The various slightly different forms of fibronectin appear to be generated by tissue specific differential splicing of fibronectin mrna, transcribed from a single gene. Fibronectins have multiple domains that confer the ability to interact with many extracellular substances such as collagen, fibrin and heparin and also with specific membrane receptors on responsive cells. Notable is the RGD domain recognised by integrins and two repeats of the egf like domain. Interaction of a cells fibronectin receptors (members of the integrin family) with fibronectin adsorbed to a surface results in adhesion and spreading of the cell.


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Need help and opinions ASAP.

... a set of experiments to verify the following statement: Rap2, not Rap1, is critically needed for the adehsion of smooth muscle cells to fibronectin.""" now this statement may not be scientifically valid and the experiments may not be true too, also the compounds that are ...

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by moe20
Wed Dec 26, 2007 10:09 am
 
Forum: General Discussion
Topic: Need help and opinions ASAP.
Replies: 5
Views: 2247

The Fiber Disease

... The dull/frosted side contains the nanofibers. 3. If using a hydrogel, poly-l-lysine, lipids, or extra cellular matrix proteins such as laminin, fibronectin, or collagen, incubate the insert with these items prior to seeding. 4. Seed wells by placing “bubble” of cells directly onto disc surface. ...

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by RANDY
Thu Jan 18, 2007 3:39 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560070

Zygote Question

... to become narrower and longer. the other part involves glycoproteins in the extracellular matrix that help cells migrate along certain routs (e.g. fibronectin maybe?) the CAMs are on the surfaces of cells, and they bind to each other. One example is cadherin, i think.

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by jimmystang
Mon Jan 01, 2007 4:14 am
 
Forum: Cell Biology
Topic: Zygote Question
Replies: 4
Views: 2786

The Fiber Disease

... family 18 of glycosyl hydrolases. Three putative binding domains, a chitin binding domain, a novel polycystic kidney disease (PKD) domain, and a fibronectin type III domain, were also identified within the sequence. Pairwise comparisons of each domain to the most closely related sequences found ...

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by London
Sun Nov 05, 2006 7:55 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560070

The Fiber Disease

... separation behaviors with morphological features having characteristic length scales ranging from 10nm to 1mm. Experiments and simulations of fibronectin adsorption onto different homopolymer thin-film surfaces suggest that nano- and mesoscale phase separation may influence the adsorption ...

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by Nadas Moksha
Sun Oct 22, 2006 4:54 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560070
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