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Extracellular matrix

Extracellular matrix

Any material produced by cells and secreted into the surrounding medium, but usually applied to the noncellular portion of animal tissues. The ecm of connective tissue is particularly extensive and the properties of the ecm determine the properties of the tissue. In broad terms there are three major components: fibrous elements particularly collagen, elastin or reticulin), link proteins (e.g. Fibronectin, laminin) and space filling molecules (usually glycosaminoglycans). The matrix may be mineralised to resist compression (as in bone) or dominated by tension resisting fibres (as in tendon). The basal lamina of epithelial cells is another commonly encountered ecm. Although ecm is produced by cells, it has recently become clear that the ecm can influence the behaviour of cells quite markedly, an important factor to consider when growing cells in vitro: removing cells from their normal environment can have far reaching effects.

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Xenobiotic Agents for Biofilm Prevention and Treatment

... are a serious problem in the clinic due to three key factors: (1) the extracellular matrix limits diffusion of molecules such as antibiotics, preventing them from readily accessing ...

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by bioCassie
Tue Mar 03, 2015 5:38 pm
Forum: Microbiology
Topic: Xenobiotic Agents for Biofilm Prevention and Treatment
Replies: 0
Views: 254

Free-flowing cells and those that are stuck together?

http://en.wikipedia.org/wiki/Extracellular_matrix That link talks about the extracellular matrix... hopefully it will help you answer your questions!

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by plasmodesmata11
Wed May 30, 2012 2:13 am
Forum: Cell Biology
Topic: Free-flowing cells and those that are stuck together?
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Views: 2904


Glycocalyx is only found in the extracellular matrix of cells attaching to the proteins or lipids of a plasma membrane, right? however, out of curiosity, ...

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by gqh
Sat May 12, 2012 8:27 am
Forum: General Discussion
Topic: Glycocalyx
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Extracellular "Matrix"

I know matrix basically means the nonliving external parts of cells with fibers, proteins, carbs, etc.... but is there anything else one can add to the definition of "matrix" Also, how does the matrix of bone, differ ...

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by reyrey389
Tue Nov 22, 2011 2:56 am
Forum: Cell Biology
Topic: Extracellular "Matrix"
Replies: 2
Views: 1497

Questions about Connective Tissue

... when the blasts become "trapped" or when the extracellular matrix is done forming? 4) Lastly do we say that macrophages "wander" the tissue ...

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by reyrey389
Wed Nov 16, 2011 8:34 am
Forum: Cell Biology
Topic: Questions about Connective Tissue
Replies: 1
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