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Exon

Definition

noun, plural: exons

(molecular biology)

1. The protein-coding region in the DNA.

2. The nucleic acid sequence in the DNA, or RNA transcript following genetic splicing.


Supplement

Genes contain exons which are regions coding for proteins and which are interrupted by the unused sequences called introns. Exons have been found to include both sequences coding for amino acids and untranslated sequences. The introns are removed and the exons are joined together to form the final functional mRNA.


Related forms: exonic (adjective).
Compare: intron.
See also: DNA, RNA, translation, mRNA, protein synthesis.


User Contributions / Comments:

  • The base sequences that appear in eukaryotic DNA and are used to make mRNA for a specific protein are the exons of a gene.

(~Dlee7283)


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


Gene knockdowns in the wasp Nasonia vitripennis

... genes. To overcome this limitation, we designed an Nv eve morpholino overlapping the translation start site, as well as one directed at the exon-intron junction in the homeobox. These two independent morpholinos are expected to disrupt Nv eve activity and indeed result in comparable phenotypes." ...

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by jonmoulton
Fri Mar 07, 2014 5:57 pm
 
Forum: Molecular Biology
Topic: Gene knockdowns in the wasp Nasonia vitripennis
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Views: 55

Re: qPCR vs Northern Blot

... first - in Northern blot I had silencing, in qPCR i didn't. As far as your question is concerned - my NB probe covers whole length of mRNA - all exons (it's a short one ~2 kbp total). In case of my PCR primers - FORWARD primer binds in one exon in the middle of mRNA, and REVERSE binds at exon-exon ...

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by Nevthonien
Tue Nov 12, 2013 2:47 pm
 
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Topic: qPCR vs Northern Blot
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Review of exon skipping for human therapeutics

Mullard A. Make or break for first splice-modulating agents. Nat Rev Drug Discov. 2013 Oct 31;12(11):813-5. doi: 10.1038/nrd4151. No abstract available. http://www.nature.com/nrd/journal/v12/n11/full/nrd4151.html This is an interest of mine, as my wife was involved in development of ...

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by jonmoulton
Mon Nov 04, 2013 8:51 pm
 
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Topic: Review of exon skipping for human therapeutics
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Views: 520

Aligning RNA to genomic DNA

... have a recommendation for gap open penalty and extension penalty setting - what I'm trying to do is to align an RNA seqeunce which is compose of exon 1 and 2 to a genomic DNA - however so far it I can only align either exon 1 or 2 but not both because there is a huge intronic gap in the gDNA. ...

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by simplitia
Wed Sep 25, 2013 6:53 pm
 
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Topic: Aligning RNA to genomic DNA
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Views: 730

Re:

that would suggest there is some small alternative-intron in your exon, which can be thus split why are you using primers only for one exon at a time? Is your aim to clone all variants or are you fine with only some? Well, we initially had 4 sets of primers. ...

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by polkadotshorts
Mon Dec 10, 2012 7:12 pm
 
Forum: Genetics
Topic: How to clone a gene with lots of splicing intermediates?
Replies: 6
Views: 2507
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