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Excision repair

Excision repair

(Science: molecular biology) mechanism for the repair of environmental damage to one strand of dna (loss of purines due to thermal fluctuations, formation of pyrimidine dimers by uv irradiation).

The site of damage is recognised, excised by an endonuclease, the correct sequence is copied from the complementary strand by a polymerase and the ends of this correct sequence are joined to the rest of the strand by a ligase. The term is sometimes restricted to bacterial systems where the polymerase also acts as endonuclease.

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Mismatch DNA repair

Base excision and nucleotide excision based DNA repair in E. coli use DNA polymerase I but the DNA mismatch repair of the daughter strand (unmethylated) uses DNA ...

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by hullah
Wed Nov 10, 2010 5:31 am
Forum: Molecular Biology
Topic: Mismatch DNA repair
Replies: 4
Views: 3691

Re: What is a strand bias

... (21) and in mammalian cells (22), transcription-blocking lesions are repaired preferentially when present in the transcribed strand. Transcription-coupled nucleotide excision repair has helped explain the observed bias in mutations caused by mutagens such ...

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by sorin
Wed Sep 29, 2010 3:33 pm
Forum: Genetics
Topic: What is a strand bias
Replies: 4
Views: 7021

What is a strand bias

... strand(non trancribing strand).The article says that it doesn't get repaired by nucleotide excision repair system because the repair system is biased.I need help in understanding the ...

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by bertstare
Tue Sep 28, 2010 4:03 pm
Forum: Genetics
Topic: What is a strand bias
Replies: 4
Views: 7021

Complementary Base Pairing

Perhaps the DNA repair checkpoints during the cell cycle? If there is not complementary base pairing (mismatched pairing) then the cell cycle will halt until the DNA repair is done (excision of mismatched pair and replacement of correctly complementary base pairing put in).

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by kolean
Thu Oct 29, 2009 12:31 am
Forum: Cell Biology
Topic: Complementary Base Pairing
Replies: 5
Views: 5543

The Fiber Disease

... information. For example, the proteins involved in the recombinosome or repairosome have been clustered. The extraction of this knowledge was not ... genes with related functions and or physical interactions– nucleotide excision repair, DNA end-joining etc. Many elements are missing in the retrieved ...

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by Nadas Moksha
Fri Nov 17, 2006 6:38 pm
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6264527
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