Epistasis is the interaction between the genes at two or more loci, so that the phenotype differs from what would be expected if the loci were expressed independently. The gene whose phenotype is expressed is said to be epistatic, while the phenotype altered or suppressed is said to be hypostatic.Epistasis is the process of a gene being masked by a mutation.

Example of Epistasis Although the gene for male-pattern baldness is not located on the X chromosome, the sex of the individual determines whether the allele for baldness is dominant or recessive. In males the baldness allele is dominant while in females the baldness allele is recessive. Here, the baldness allele will be represented by B' while the non-baldness alleles will be represented by B.

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