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Enhancer element

Enhancer element

(Science: molecular biology) a dna sequence, present in the genomes of higher eukaryotes and of various animal viruses, which can increase the transcription of genes into messenger rna.

These control element frequently found 5' to the start site of a gene, when bound by a specific transcription factor, enhance the levels of expression of the gene, but are not sufficient alone to cause expression.

Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound, in practice, the two terms merge.

enhancers usually can function in either orientation and at various distances from a promoter.

Compare: promoter.


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cloning

Hello, I would like to insert an enhancer element into a cis-reporter plasmid (luciferase) to test promoter activity of my gene of insert. I found ...

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by kk
Tue May 31, 2011 9:30 am
 
Forum: Molecular Biology
Topic: cloning
Replies: 10
Views: 5112

Re: upstream downstream

... region but lies "upstream" of the start site. A cis-acting element must act on the same segment of "gene" (it usually is DNA, ... a part of, so a cis-acting upstream element is something (a promoter or enhancer, say) that lies 5' to the transcribed gene, and is involved in the ...

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by blcr11
Tue Aug 26, 2008 12:13 pm
 
Forum: Genetics
Topic: upstream downstream
Replies: 1
Views: 5923

The Fiber Disease

... Transposons Gene disruption mediated by transposable elements or transposons that occur in a variety of organisms including zebrafish ... for gene trapping and insertional mutagenesis of zebrafish (90, 93). Enhancer traps, gene traps, and other traps based on these systems have significant ...

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by codon blue
Tue Nov 14, 2006 9:12 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 4988344

The Fiber Disease

... that humans were exposed to SV40 viruses with both one 72-bp enhancer and two 72-bp enhancers SV40 through contaminated vaccines. Our ... region (RR) of simian virus 40 (SV40) contains enhancer/promoter elements and an origin of DNA replication. Natural SV40 isolates from simian ...

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by Skytroll
Thu Sep 14, 2006 11:32 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 4988344


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