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Endotoxin

Endotoxin

(Science: protein) heat stable polysaccharide like toxin bound to a bacterial cell. The term is used more specifically to refer to lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria. There are three parts to the molecule, the lipid a (six fatty acid chains linked to two glucosamine residues), the core oligosaccharide (branched chain of ten sugars) and a variable length polysaccharide side chain (up to 40 sugar units in smooth forms) that can be removed without affecting the toxicity (rough LPS). Some endotoxin is probably released into the medium and endotoxin is responsible for many of the virulent effects of gram-negative bacteria.


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Re: Bacteriophages and Acne?

Propionibacteria are Gram postive - so no classic endotoxin (LPS) tho' debris could still be a concern. But assuming topical application, this may be less of a worry. Bacteriophage therapy also suffers from host rimmune response to the phage itself, ...

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by JorgeLobo
Sun Apr 01, 2012 8:59 pm
 
Forum: Microbiology
Topic: Bacteriophages and Acne?
Replies: 9
Views: 11191

Bacteria w/ Antibiotic Treatment

Yes - the LPS (endotoxin) release from killing all the bacteria so quickly has bad effects on your immune system, in the form of endotoxic shock. This is generally the case to at least some degree for any Gram negative bacterium, ...

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by AstraSequi
Wed Feb 15, 2012 3:27 am
 
Forum: Microbiology
Topic: Bacteria w/ Antibiotic Treatment
Replies: 2
Views: 1623

Bacteria w/ Antibiotic Treatment

... intracellular when alive, are degraded, and their LPS (the lipid A moiety specifically) is presented on the cells to the immune system, causing an endotoxin response.

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by WntScientist
Tue Feb 14, 2012 8:12 am
 
Forum: Microbiology
Topic: Bacteria w/ Antibiotic Treatment
Replies: 2
Views: 1623

Re: doubt about Detoxi-Gel™ Endotoxin Removing Gel

these 2 sentense could not consistent, i am confusing. these 2 sentences could not consider/understand(?), I'm confused :wink: Well, I found only this http://www.piercenet.com/files/0415dh5.pdf You probably do not know, what is bed or void volume. The void volume is volume of liquid in the column, ...

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by JackBean
Fri Jan 08, 2010 8:33 am
 
Forum: Cell Biology
Topic: doubt about Detoxi-Gel™ Endotoxin Removing Gel
Replies: 7
Views: 3315

doubt about Detoxi-Gel™ Endotoxin Removing Gel

Hi there these days i will purify my samples with Detoxi-Gel™ Endotoxin Removing Gel, but i could not understand protocol very well. 1 with a gravity-flow column, the sample will begin to emerge from the column about 90% of the bed volumn has been collected. ...

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by jasmina
Fri Jan 08, 2010 4:41 am
 
Forum: Cell Biology
Topic: doubt about Detoxi-Gel™ Endotoxin Removing Gel
Replies: 7
Views: 3315
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