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Endotoxin

Endotoxin

(Science: protein) heat stable polysaccharide like toxin bound to a bacterial cell. The term is used more specifically to refer to lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria. There are three parts to the molecule, the lipid a (six fatty acid chains linked to two glucosamine residues), the core oligosaccharide (branched chain of ten sugars) and a variable length polysaccharide side chain (up to 40 sugar units in smooth forms) that can be removed without affecting the toxicity (rough LPS). Some endotoxin is probably released into the medium and endotoxin is responsible for many of the virulent effects of gram-negative bacteria.


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Methylene Blue Solution use in staining variety of bacteria?

... and other bacteria of the stomach, are more pathogenic. Gram negative bacterial cell walls are composed of lipopolysaccharides that can be an endotoxin (toxic shock syndrome). Gram stain experiments are another type of a multi-step staining and de-staining experiment. Reagents 0.1M Sodium ...

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by scytek
Sun Feb 22, 2015 9:22 am
 
Forum: General Discussion
Topic: Methylene Blue Solution use in staining variety of bacteria?
Replies: 0
Views: 268

Bacteria w/ Antibiotic Treatment

I don't know why the patient died. But I think after the bacteria killed due to antibiotic, immune system rapidly clear the endotoxin.

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by josem
Tue Oct 07, 2014 8:49 pm
 
Forum: Microbiology
Topic: Bacteria w/ Antibiotic Treatment
Replies: 3
Views: 3075

Re: Bacteriophages and Acne?

Propionibacteria are Gram postive - so no classic endotoxin (LPS) tho' debris could still be a concern. But assuming topical application, this may be less of a worry. Bacteriophage therapy also suffers from host rimmune response to the phage itself, ...

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by JorgeLobo
Sun Apr 01, 2012 8:59 pm
 
Forum: Microbiology
Topic: Bacteriophages and Acne?
Replies: 9
Views: 15413

Bacteria w/ Antibiotic Treatment

Yes - the LPS (endotoxin) release from killing all the bacteria so quickly has bad effects on your immune system, in the form of endotoxic shock. This is generally the case to at least some degree for any Gram negative bacterium, ...

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by AstraSequi
Wed Feb 15, 2012 3:27 am
 
Forum: Microbiology
Topic: Bacteria w/ Antibiotic Treatment
Replies: 3
Views: 3075

Bacteria w/ Antibiotic Treatment

... intracellular when alive, are degraded, and their LPS (the lipid A moiety specifically) is presented on the cells to the immune system, causing an endotoxin response.

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by WntScientist
Tue Feb 14, 2012 8:12 am
 
Forum: Microbiology
Topic: Bacteria w/ Antibiotic Treatment
Replies: 3
Views: 3075
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