Endothelium

I have same basic questions. I have a problem defining what carcinoma means: a tumour originating in the epithelium, or can it also come from endothelium, or basically any tissue that derives from the embryonic ectoderm? Same with sarcoma: any type of tumour that has the origin in the mesoderm? ...

See entire post

... is caused by the build up of cholesterol and other fatty substances in walls of arteries. Firstly the deposits form small streaks on the endothelium of the artery, but gradually build up to form patches known as atheromatous plaques. The deposit is called an atheroma and causes the arterial ...

See entire post

... storm" has various effects, of which increased vascular permeability is perhaps the most dangerous one. The cytokines affect the vascular endothelium in a way that increases the vascular diameter and blood flow, and allows fluid (and immune cells) to quickly pass through the vascular walls ...

See entire post

what sort of effects would massive cytokine release caused by viral infection of monocytes & macrophages have on the vascular endothelium? am i right in assuming it would lead to vascular instability?

See entire post

... cells" are indeed macrophages full of endocytosed LDL droplets and other debris that is associated with excess lipids stuck on the vascular endothelium :)

See entire post