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Definition

noun

The reagent used in Edman method of protein degradation to react with the amine group of the N-terminal amino acid

Supplement

Edman's reagent or phenylisothiocyanate is one of the many reagents used to label terminal amino acids. It reacts with the free N-terminal amino group of a peptide chain to ultimately form a phenylthiohydantoin for the identification of N-terminal amino acids.

Synonym(s):

• phenylisothiocyanate
• isothiocyanic acid
• phenyl ester
• isothiocyanatobenzene
• thiocarbanil

See also:

• Edman degradation

Mentioned in:

• PTC protein