E2F transcription factor 2
E2F transcription factor 2 genes are mapped on chromosome 1p36 that embrace two main functions such as transcription activators and repressors that help to carry out cell cycle. It also acts in DNA repair and replication of proteins that targets the transforming proteins of small DNA tumor viruses.
E2F transcription factor 2 contains several evolutionary conserved domains found in most members of the family which includes DNA binding domain, dimerization domain and transactivation domain that is enriched in acidic amino acids. It also appears to play a vital role in angiogenesis through the activation of vascular endothelial growth factor.
E2F transcription factor 2 mutation or overexpression inhibits serum induction of the cyclin A promoter that contributes to the phenotypes of reduced chondrocyte proliferation and dwarfism. Activator E2F2 proteins can transcribe S phase promoting genes and cyclic with maximal expression during G1/S transition.
Gene name: E2F2
Protein name: Transcription factor E2F2