Dictionary » D » Duchenne muscular dystrophy

Duchenne muscular dystrophy

Duchenne muscular dystrophy

a specific form of muscular dystrophy that is inherited as a sex-linked recessive trait and thus confined to young males and to females with turners syndrome. One third of all cases are estimated to be new mutational events.

See: dystrophin.

It is characterised by degeneration and necrosis of skeletal muscle fibres, that are replaced by fat and fibrous tissue.

symptoms include muscle weakness and in some forms, the appearance of muscle enlargement (pseudo-hypertrophy). Advanced cases can include weakness of the respiratory muscles (compromising breathing) and cardiomyopathy.

Inheritance: sex-linked recessive.

Incidence: 1 in 4000 male births.


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


Molecular medicine: antisense

... for a new medicine. Here are a few articles on Duchenne muscular dystrophy and eteplirsen, a Morpholino antisense drug currently in ...

See entire post
by jonmoulton
Thu Mar 06, 2014 4:19 pm
 
Forum: Molecular Biology
Topic: Molecular medicine: antisense
Replies: 0
Views: 642

Genetic testing: reliability, accuracy, experience?

... very straightforward, though. For example, the Duchenne muscular dystrophy requires just a single mutation in one of the alleles of ...

See entire post
by biohazard
Mon Apr 15, 2013 8:55 am
 
Forum: Genetics
Topic: Genetic testing: reliability, accuracy, experience?
Replies: 3
Views: 3999

Re: Muscular dystrophy inheritance question

Right - this is autosomal, therefore it is not Duchenne muscular dystrophy (DMD) and is not a mutation of the dystrophin gene. Thanks, ...

See entire post
by jonmoulton
Thu Jan 10, 2013 3:59 pm
 
Forum: Molecular Biology
Topic: Muscular dystrophy inheritance question
Replies: 7
Views: 5504

Novel compounds for treating Duchenne muscular dystrophy

... S. Novel compounds for the treatment of Duchenne muscular dystrophy: emerging therapeutic agents. The Application of Clinical ...

See entire post
by jonmoulton
Thu Mar 10, 2011 6:11 pm
 
Forum: Genetics
Topic: Novel compounds for treating Duchenne muscular dystrophy
Replies: 0
Views: 1044

Review: Exon Skipping as a Therapeutic Approach to Duchenne

... of Exon Skipping as a Therapeutic Approach to Duchenne Muscular Dystrophy A nice new review of Morpholinos (PMO) and 2'-O-Me phosphorothioate ...

See entire post
by jonmoulton
Thu Oct 28, 2010 9:36 pm
 
Forum: Genetics
Topic: Review: Exon Skipping as a Therapeutic Approach to Duchenne
Replies: 1
Views: 5027
View all matching forum results

This page was last modified 21:16, 3 October 2005. This page has been accessed 3,075 times. 
What links here | Related changes | Permanent link