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DsDNA virus



Any of the viruses belonging to the Class I of Baltimore classification system characterized by having a double stranded DNA as the genetic material and using a DNA-dependent DNA polymerase during replication.


Most of these viruses must enter the host nucleus before they can replicate. It is because they use the host cell's polymerases when replicating their viral genome. They can induce the cell to undergo cell division, which further leads to transformation of the cell, and ultimately, to cancer.

Examples include adenoviruses, herpesviruses, poxviruses, etc.

Compare: ssDNA virus.
See also: DNA virus.

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"Model organism" for viruses?

if you want to study basic biology of the viruses (e.g. how they enter the cell, how they replicate etc.), you should use the same kind of virus you are interested in (like dsDNA virus with envelope). However, mostly you will probably use right the one you are ...

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by JackBean
Thu Oct 20, 2011 7:14 am
Forum: Microbiology
Topic: "Model organism" for viruses?
Replies: 3
Views: 1478

Can influenza be used as a viral vector in gene therapy

... @prometheus: what about herpes simplex? it doesn't integrate but it has dsDNA that can remain inside the nucleus of nerve cells for years. it is ... acyclovir which inhibits its DNA polymerase, but that won't get rid of virus for sure. And one can always imagine mutations that would render the ...

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by MrMistery
Fri Oct 16, 2009 3:28 am
Forum: Microbiology
Topic: Can influenza be used as a viral vector in gene therapy
Replies: 10
Views: 5624

HIV Reverse Transcriptase Enzyme

... at least describes in some detail the steps of infection as well as virus production and maturation is given by: http://aids.about.com/od/newlydiagnosed/ss/livecycle_10.htm ... pools of dNTP, thus activating RT. The action of RT is to produce a dsDNA copy of the viral RNA with a few “extras” on ...

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by blcr11
Thu Jul 19, 2007 10:18 pm
Forum: Molecular Biology
Topic: HIV Reverse Transcriptase Enzyme
Replies: 3
Views: 5930

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