Donath-landsteiner cold autoantibody

Donath-landsteiner cold autoantibody

An autoantibody of the igg class responsible for paroxysmal cold haemoglobinuria; it is adsorbed to red cells only at temperatures of 20�C or lower, causing the red cells to lyse in the presence of complement at higher temperatures; it has only slight agglutinating properties in spite of its marked lytic activity, and has a specificity within the blood group P; it is also occasionally present for short periods of time following measles and other infections, and formerly was frequently associated with syphilis.

Synonym: cold haemolysin.

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