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Dnase i sensitivity

Dnase i sensitivity

(Science: molecular biology) The likelihood that a particular dna segment will be attacked by the endonuclease enzyme dnase i, which breaks down dna into smaller fragments by cleaving its phosphodiester bonds. Dna segments which contain active genes that are regularly transcribed are more prone to being cut apart by dnase i than inactivated genes, because the inactivated genes are generally within condensed regions of the chromosome, while the active genes are in more open configurations for easy access for transcription.

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Devising Experiments to Determine Positive Regulation

... in B and C? By experiment I mean, EMSA, Northern / Southern Blotting, DNase Sensitivity assay etc. Any ideas?

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by niravana21
Mon Mar 07, 2011 5:49 am
Forum: Cell Biology
Topic: Devising Experiments to Determine Positive Regulation
Replies: 1
Views: 875

Beta Receptors

... just now...it says that active sites of transcription show increased sensitivity to digestion with DNase (B-globin experiemnt)---so this must mean (putting it simply) that these sites are easily ...

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by biology_06er
Sat Jun 02, 2007 1:11 am
Forum: Physiology
Topic: Beta Receptors
Replies: 7
Views: 5030

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