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Dna methylation

Dna methylation

(Science: molecular biology) process by which methyl groups are added to certain nucleotides in genomic dna.

this affects gene Expression, as methylated dna is not easily transcribed. The degree of methylation is passed on to daughter strands at mitosis by maintainance dna methylases. Accordingly, dna methylation is thought to play an important developmental role in sequentially restricting the transcribable genes available to distinct cell lineages.

in bacteria, methylation plays an important role in the restriction systems, as restriction enzymes cannot cut sequences with certain specific methylations.


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Paramutation

Hey..does anyone know what's molecular basis of paramutation?Does it also involves methylation or..It was discovered in corn but if anyone knows some examples in mammals I would be thankful...

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by zami'87.
Thu Aug 20, 2009 6:11 pm
 
Forum: Molecular Biology
Topic: Paramutation
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Views: 105

Genomic Imprinting In Humans (and classical genetics)

Methylation of histones. The allele is wrapped around the histones, and when their tails are methylated, the histones stay closely condense and do not let any transcription factors bind to their elements for transcription. ...

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by kolean
Mon Jul 20, 2009 9:12 pm
 
Forum: Genetics
Topic: Genomic Imprinting In Humans (and classical genetics)
Replies: 7
Views: 342

Genomic Imprinting In Humans (and classical genetics)

As I understand it, imprinting is a chemical change in the DNA in the allele - methylation of some sort - that is potentially reversible. It affects expression of the allele ...

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by Darby
Sun Jul 19, 2009 4:23 pm
 
Forum: Genetics
Topic: Genomic Imprinting In Humans (and classical genetics)
Replies: 7
Views: 342

Really puzzled with gene expresseion!!!!

Depending upon the depth of the answer you're looking for, try a search on expression and methylation as well.

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by Darby
Sun Apr 26, 2009 8:00 pm
 
Forum: Genetics
Topic: Really puzzled with gene expresseion!!!!
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PCR questions

... and/or Quantitative RT-PCR Degenerate PCR In Situ PCR Differential Display PCR Inverse PCR Ligation Mediated Suppression PCR Long PCR Protocols Methylation Specific PCR Multiplex PCR Nested PCR PCR Elisa PCR Brochure and Articles RACE PCR RAPD PCR REP-PCR Tail PCR Touchdown PCR Vectorette PCR ...

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by biolearner
Thu Nov 27, 2008 9:34 pm
 
Forum: Molecular Biology
Topic: PCR questions
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