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Dna adducts

Dna adducts

covalent adducts between chemical mutagens and dna. Such couplings activate dna repair processes and, unless repaired prior to dna replication, may lead to nucleotide substitutions, deletions, and chromosome rearrangements. (rieger et al., glossary of genetics: classical and molecular, 5th ed)


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Please comment this theory, is this theory correct?

... theory is that the radical flavonoid (like quercetin) molecule forms a DNA adduct, like mutagenic substances form a DNA adduct and causes DNA to ... bind to DNA, which makes it able for the radical flavonoid to form adducts on DNA. Then, if the DNA adduct isn't removed before cell division ...

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by schang1984
Fri Aug 23, 2013 1:17 pm
 
Forum: Cell Biology
Topic: Please comment this theory, is this theory correct?
Replies: 5
Views: 4438

poly(dεA)

... they discovered in the mid 1980s. I haven’t seen any good explanation as to why the fluorescence increases on binding. My guess is that adjacent adducts (or other bases, even) quench the intrinsic fluorescence of the adduct. Binding to protein disrupts the interbase interactions and thus enhances ...

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by blcr11
Mon Sep 10, 2007 5:03 pm
 
Forum: Molecular Biology
Topic: poly(dεA)
Replies: 1
Views: 1490

The Fiber Disease

... The process is based on the incorporation of SO(sub2) into the colorless crystals and the subsequent liberation of the gas from the orange adducts by reversible bond formation and cleavage. The authors suggest such crystalline materials will find applications for gas storage devices and ...

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by London
Fri Aug 11, 2006 2:13 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560690

Inactivating signal transduction pathway?

... in the receptor protein that cause it to have a much lower Ka (binding efficiency) to the hormone. Or you can modify the cell membrane with adducts to render the membrane proteins unable to bind the hormone. Also, since Calcium Ca+2 is key to signal transduction, you can add chemical such ...

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by Jumpshooter
Thu Dec 15, 2005 4:06 pm
 
Forum: Cell Biology
Topic: Inactivating signal transduction pathway?
Replies: 3
Views: 2093


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