Dictionary » D » Disulphide bond

Disulphide bond




(1) The single covalent bond formed from the coupling of thiol groups, especially of cysteine residues.

(2) The linkage formed by the oxidation of two SH groups, each attached to a cysteine, stabilizing the structure of many protein molecules (during protein synthesis).


Disulphide bonds play an important role in the folding and stability of some proteins, usually proteins secreted to the extracellular medium.

Below is an example of a disulphide bond:

Cysteine---SH + HS---Cysteine → Cysteine---S-S---Cysteine + 2H+ + 2e-

Two cysteines linked by a disulphide bond forms a cystine.

Variant: disulfide bond

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Re: Denaturation of enzymes

... to the stability of individual molecules and individual sections, that bonds reform in a different order than when the protein was first created? ... bonds (along the entire primary structure) that form first, followed by disulphide bonds. What if a single disulphide bond were to form first, before ...

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by carmenh
Fri Feb 27, 2009 10:21 pm
Forum: General Discussion
Topic: Denaturation of enzymes
Replies: 3
Views: 103695


... region, C terminus on constant region, connected to each other by disulphide bond -S-S- The structure of T cell receptor (TCR), the region, is somewhat similar to Fab of ...

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by Dr.Stein
Tue Jul 26, 2005 10:01 am
Forum: General Discussion
Topic: interferon
Replies: 44
Views: 20657

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