Dictionary » D » Dissociation constant

Dissociation constant

Definition

noun

(1) A mathematical constant that describes the tendency of a large molecule to dissociate reversibly into smaller components.

(2) The equilibrium constant in a dissociation reaction.


Supplement

Dissociation constant is a type of equilibrium constant that specifically involves the measure of the propensity of dissociation of a complex molecule into its subcomponents. An example of its application is to describe how tightly a ligand binds to a particular protein.


Also called: equilibrium dissociation constant, ionization constant.

Symbol: Kd

Compare: association constant


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Interactions between genes: in cancer and normal cells.

every interaction is in equilibrium quatified by dissociation constant K_D, so it depends on the levels of both proteins and on the K_D ;)

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by JackBean
Thu Aug 25, 2011 9:04 pm
 
Forum: Genetics
Topic: Interactions between genes: in cancer and normal cells.
Replies: 2
Views: 5598

Re: I need some help on these question

... pretty much guess how will it react. 8. Write the equation for the dissociation of water, and explain what is actually transferred from one ... you mean by this. Basically, you have some dissociation equation and constant (as above) and from this by minus log you get the pH... 11. Explain ...

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by JackBean
Sun Sep 12, 2010 9:39 am
 
Forum: Cell Biology
Topic: I need some help on these question
Replies: 1
Views: 7609

Dissociation Constants

Quick question of clarification, If a particular receptor has a dissociation constant (Kd) of 50nM for instance. That means that the receptor is half bound by ligand when ...

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by pmngrad
Sun May 16, 2010 7:06 pm
 
Forum: Molecular Biology
Topic: Dissociation Constants
Replies: 1
Views: 1091

Free drug concentration

... I don't get it. Anyway, it doesn't make much sense to substract/add the dissociation constant from/to protein/drug amount

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by JackBean
Sun Oct 25, 2009 1:36 pm
 
Forum: Molecular Biology
Topic: Free drug concentration
Replies: 3
Views: 2373

Free drug concentration

Sorry its addition of dissociation constant. but formula does not say multiplication of dissociation constant.

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by carbonp
Sun Oct 25, 2009 1:30 pm
 
Forum: Molecular Biology
Topic: Free drug concentration
Replies: 3
Views: 2373
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