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Differentiation

Definition

noun

(developmental biology) The normal process by which a less specialized cell develops or matures to become more distinct in form and function.

(medicine) The determination of which among the diseases with similar symptoms is the one that the patient is suffering, especially through a systematic method.


Supplement

(developmental biology) For example, a single-celled zygote develops into a multicellular embryo that further develops into a more complex multisystem of various cell types of a fetus. The cell size, shape, polarity, metabolism and responsiveness to signals change dramatically such that the less specialized cell becomes more specialized and acquires a more specific role.

Compare: dedifferentiation.

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Stem and Progenitor Cell Questions

... 4 cell stage of many zygotes are totipotent. In that, you can separate the 4 cells and they will form 4 perfect organisms. After the 4 cell stage, differentiation of the cell has begun and the cells when pulled apart will follow only a lineage (a mass of mesencymal tissue, or endodermal tissue, ...

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by kolean
Wed Sep 02, 2009 11:08 pm
 
Forum: Cell Biology
Topic: Stem and Progenitor Cell Questions
Replies: 2
Views: 27

multiple initiation sites.

... also, are being attached and preparing the chromatin for the rest of the cell cycle. The chromatin modeling proteins prepare the cell to keep its differentiation and thus epigenetic expression, upon replication.

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by kolean
Thu Aug 20, 2009 2:42 am
 
Forum: Cell Biology
Topic: multiple initiation sites.
Replies: 5
Views: 95

Anti-metastasis and Cytostasis, Differentiation between the

:) Hi all, I am currently working on 2 compounds which have shown inhibition of migration when wound healing assay was used. I just wanted to make sure the inhibition was because of the anti-metastatic activity of the compounds, but not because of the cytostatic nature. I am currently using the C6, ...

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by Gemini
Fri Jul 17, 2009 3:40 pm
 
Forum: Cell Biology
Topic: Anti-metastasis and Cytostasis, Differentiation between the
Replies: 0
Views: 163

Re: ?{REGENERATION}? Is it possible ???!!

Can you clarify the distinction between "transdifferentiation" and the "dedifferentiation and then differentiation" that occurs during epimorphic regeneration? Is it just the process of reployment of developmental programming during ...

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by kolean
Mon Jun 29, 2009 1:42 pm
 
Forum: Cell Biology
Topic: ?{REGENERATION}? Is it possible ???!!
Replies: 31
Views: 1639

?{REGENERATION}? Is it possible ???!!

kolean, i would like you to be right, but i fear that the more we look at in vivo dedifferentiation followed by differentiation into another cell type we see that it might not be a viable treatment option. right now it seems to me that transdifferentiation might be ...

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by MrMistery
Sun Jun 28, 2009 5:17 pm
 
Forum: Cell Biology
Topic: ?{REGENERATION}? Is it possible ???!!
Replies: 31
Views: 1639
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