Diacylglycerol

... cell membrane. The phospholipase travels to the nuclear membrane. There, the phospholipase catalyzes ester hydrolysis of phospholipid (by A2) or diacylglycerol (by phospholipase C). This frees a 20-carbon essential fatty acid. This hydrolysis appears to be the rate-determining step for eicosanoid ...

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first the acyl bond with one fatty acid is hydrolyzed, yeilding diacylglycerol. then a second bond is hydrolyzed, yielding monoacylglycerol. then the third one, and you are left with glycerol and 3 free fatty acid molecules

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... receptor activation. 2. GPCRs that activate PLC-g leading to hydrolysis of polyphosphoinositides (e.g. PIP2) generating the second messengers, diacylglycerol (DAG) and inositoltrisphosphate (IP3). This class of receptors includes the angiotensin, bradykinin and vasopressin receptors. 3. A novel ...

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Well it says that something was cleaved, I'm betting the original substance is composed of phosphorylcholine+diacylglycerol which is the substrate.

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... produced by the phospholipase treatment showed an enormous increase in free phosphorylcholine (choline with a phosphate group attached) and diacylglycerol (glycerol with two fatty acids attached) A) What is the substrate for the phospholipase and where is it cleaved? B) In light of what ...

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