Dictionary » D » Diacylglycerol

Diacylglycerol

Diacylglycerol

glycerol substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. Dag is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase c activity. Dag from phosphatidyl inositol polyphosphates is important in signal transduction. Elevated levels of dag in membranes activate protein kinase c by stabilising its catalytically active complex with membrane bound phosphatidyl serine and calcium.


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Re: molecular mechanism of inflammation

... cell membrane. The phospholipase travels to the nuclear membrane. There, the phospholipase catalyzes ester hydrolysis of phospholipid (by A2) or diacylglycerol (by phospholipase C). This frees a 20-carbon essential fatty acid. This hydrolysis appears to be the rate-determining step for eicosanoid ...

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by jwalin
Mon Jan 18, 2010 9:56 am
 
Forum: Molecular Biology
Topic: molecular mechanism of inflammation
Replies: 9
Views: 6541

Proteolysis of protease

first the acyl bond with one fatty acid is hydrolyzed, yeilding diacylglycerol. then a second bond is hydrolyzed, yielding monoacylglycerol. then the third one, and you are left with glycerol and 3 free fatty acid molecules

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by MrMistery
Sun Mar 01, 2009 2:51 pm
 
Forum: Molecular Biology
Topic: Proteolysis of protease
Replies: 5
Views: 5281

G-proteins

... receptor activation. 2. GPCRs that activate PLC-g leading to hydrolysis of polyphosphoinositides (e.g. PIP2) generating the second messengers, diacylglycerol (DAG) and inositoltrisphosphate (IP3). This class of receptors includes the angiotensin, bradykinin and vasopressin receptors. 3. A novel ...

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by blindcat35
Sat Feb 04, 2006 6:31 am
 
Forum: Cell Biology
Topic: G-proteins
Replies: 4
Views: 6799

Congo river

Well it says that something was cleaved, I'm betting the original substance is composed of phosphorylcholine+diacylglycerol which is the substrate.

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by mith
Fri Apr 01, 2005 2:55 am
 
Forum: Molecular Biology
Topic: Congo river
Replies: 2
Views: 3799

Congo river

... produced by the phospholipase treatment showed an enormous increase in free phosphorylcholine (choline with a phosphate group attached) and diacylglycerol (glycerol with two fatty acids attached) A) What is the substrate for the phospholipase and where is it cleaved? B) In light of what ...

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by om09404n
Fri Apr 01, 2005 12:47 am
 
Forum: Molecular Biology
Topic: Congo river
Replies: 2
Views: 3799


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