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Defensins

Defensins

(Science: biochemistry) family of small (30-35 residue) cysteine rich cationic proteins found in vertebrate phagocytes (notably the azurophil granules of neutrophils) and active against bacteria, fungi and enveloped viruses. Research hints that some members of this family display selectively cytotoxic effects towards host cancer cells.

May constitute up to 5% of the total protein. Insect defensins have some sequence homology with the vertebrate forms.


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The Fiber Disease

... by proteases and hydrolases secreted by competitive microorgan- isms or against bacterio- and fungicidal proteins of animal origin, such as defensins, magainins or pro- tegrins (Doering et al., 1999; Rosas & Casadevall, 2001). The protective role of melanin is mainly based on the inactivation ...

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by Nadas Moksha
Thu Oct 26, 2006 3:39 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
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The Fiber Disease

... and a link between innate and adaptive immunity. Additional protection comes from polypeptide mediators of the innate host defense, such as the defensins and other antibiotic peptides. In view of the considerable burden in terms of mortality and morbidity that severe infections still pose worldwide, ...

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by London
Thu Jun 01, 2006 7:11 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5479344


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