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Dictionary » D » Dedifferentiation

Dedifferentiation

Definition

noun

A cellular process in which a differentiated cell loses its special form or function, or reverts to an earlier developmental stage.


Supplement

This process is often seen in lower life forms such as worms and amphibians as a regenerative mechanism.


Word origin: de- + differentiation.
Related forms: dedifferentiate (verb), dedifferentiated (adjective).

Compare: differentiation.
See also: cellular differentiation.


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Re: ?{REGENERATION}? Is it possible ???!!

Can you clarify the distinction between "transdifferentiation" and the "dedifferentiation and then differentiation" that occurs during epimorphic regeneration? Is it just the process of reployment of developmental programming during the latter, ...

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by kolean
Mon Jun 29, 2009 1:42 pm
 
Forum: Cell Biology
Topic: ?{REGENERATION}? Is it possible ???!!
Replies: 31
Views: 1639

?{REGENERATION}? Is it possible ???!!

kolean, i would like you to be right, but i fear that the more we look at in vivo dedifferentiation followed by differentiation into another cell type we see that it might not be a viable treatment option. right now it seems to me that transdifferentiation might ...

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by MrMistery
Sun Jun 28, 2009 5:17 pm
 
Forum: Cell Biology
Topic: ?{REGENERATION}? Is it possible ???!!
Replies: 31
Views: 1639

?{REGENERATION}? Is it possible ???!!

... block fibrosis (scar tissue formation) and proceed to epithelial cells disengaging from the basement membrane and sliding over the wound opening. Dedifferentiation of local cells to form the structure, and then transdifferentiation of the cells following the developmental genetic program and renewing ...

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by kolean
Thu Jun 25, 2009 3:52 am
 
Forum: Cell Biology
Topic: ?{REGENERATION}? Is it possible ???!!
Replies: 31
Views: 1639

The Fiber Disease

... reacquiring epithelial polarity and creating new lumens between the cells. Tubulogenesis can thus be conceptualized as occurring in two stages, dedifferentiation and re-differentiation." SOURCE: http://anatomy.ucsf.edu/Pages/mostovlabpage/index2.html ............. "But to build a tissue, ...

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by Skytroll
Fri Jul 07, 2006 5:33 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 748681

CANCER - metastasis

... go differentiation ? is it possible that tumour arises in fully differentiated cells ? I think what Poison means is cancer cells go through "dedifferentiation" i.e. cancer cells lost it's differentiated function due to uncontrolled division (and thus increase rate of mutation till the ...

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by Nite
Mon Mar 27, 2006 1:35 pm
 
Forum: Human Biology
Topic: CANCER - metastasis
Replies: 8
Views: 2385
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