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Cyclooxygenase

Cyclooxygenase

(Science: enzyme) An enzyme protein complex present in most tissues that catalyses two steps in prostaglandin biosynthesis and produces prostaglandins and thromboxanes from arachidonic acid.

The cyclooxygenase activity converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.

The cyclooxygenase activity is inhibited by aspirin like drugs, accounting for their anti-inflammatory effects.

Synonym: prostaglandin endoperoxide synthase.


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Re: molecular mechanism of inflammation

... oxygenated along any of several pathways. anti inflammatory substances usually stop this biosynthesis other few lower histamine levels or inhibit cyclooxygenase (COX) and lipoxygenase (LOX), i have lost a file that talked about how eocosonoid, histamine, COX and LOX help in inflammation :oops: ...

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by jwalin
Mon Jan 18, 2010 9:56 am
 
Forum: Molecular Biology
Topic: molecular mechanism of inflammation
Replies: 9
Views: 6577


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