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Constitutive mutant

Definition

noun

A mutant organism that continuously produces a protein (and therefore may be produced in excess) due to a mutation in the regulatory gene, which is always expressed or impossible to turn off


Supplement

Constitutive mutants are therefore those strains that continuously produce a protein, which in wild type is inducible. An example of constitutive mutant is the strain with lac operon mutation and results in the transcription of the lac genes even if lactose is not present in the medium.


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mRNA transcripts, cis/trans-acting questions

... where/how to start to figure these out. You have isolated several yeast mutants unable to metabolize galactose. All of the mutants fail to transcribe ... B -) that result in non-functional proteins. You have also isolated two constitutive regulatory mutations that you are calling m1 and m2, respectively. ...

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by animus31
Fri Nov 09, 2012 11:58 am
 
Forum: Genetics
Topic: mRNA transcripts, cis/trans-acting questions
Replies: 0
Views: 2087

Re: Experimental evidence for evolution

... Hall (41) reported the only documented case of a spontaneous Cit_ mutant in E. coli. He hypothesized that some complex mutation, or multiple ... a gene, citT, encoding a citrate– succinate antiporter. High-level constitutive expression of this gene on a multicopy plasmid allows aerobic ...

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by robsabba
Wed Jun 23, 2010 2:25 pm
 
Forum: Evolution
Topic: Experimental evidence for evolution
Replies: 103
Views: 177622

Re: Experimental evidence for evolution

... Hall (41) reported the only documented case of a spontaneous Cit_ mutant in E. coli. He hypothesized that some complex mutation, or multiple ... a gene, citT, encoding a citrate– succinate antiporter. High-level constitutive expression of this gene on a multicopy plasmid allows aerobic ...

See entire post
by jevg
Tue Jun 22, 2010 9:58 pm
 
Forum: Evolution
Topic: Experimental evidence for evolution
Replies: 103
Views: 177622


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