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Constitutive gene

Definition

noun, plural: constitutive genes

A gene that is transcribed at a relatively constant level regardless of the cell environmental conditions.


Supplement

Unlike facultative genes that are transcribed only when needed, constitutive genes are expressed continuously. It is because constitutive genes such as housekeeping genes code for products with housekeeping functions in cells, e.g. maintaining the basic cell processes or structure.

See also: constitutive enzyme, gene expression.


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cellular mechanisms that result in symptoms of cholera

... the Gs alpha subunit of the heterotrimeric G protein. This results in constitutive cAMP production, which in turn leads to secretion of H2O, Na+, ... HCO3− into the lumen of the small intestine and rapid dehydration. The gene encoding the cholera toxin is introduced into V. cholerae by horizontal ...

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by adithya528
Tue Dec 11, 2012 1:49 pm
 
Forum: Cell Biology
Topic: cellular mechanisms that result in symptoms of cholera
Replies: 4
Views: 4886

mRNA transcripts, cis/trans-acting questions

... to metabolize galactose. All of the mutants fail to transcribe the GAL2 gene, which encodes the enzyme for the first step in metabolizing galactose. ... B -) that result in non-functional proteins. You have also isolated two constitutive regulatory mutations that you are calling m1 and m2, respectively. ...

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by animus31
Fri Nov 09, 2012 11:58 am
 
Forum: Genetics
Topic: mRNA transcripts, cis/trans-acting questions
Replies: 0
Views: 2043

Can you recommend a vector?

Hi all, I am doing some mutation analysis. I have generated 4 mutants and a wild type and have been trying to transfect my cells ... is that the gene is under the control of the CMV promoter and we are getting constitutive silencing, this even happens when using a GFP reporter, where there ...

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by JimmyTee
Wed Jun 15, 2011 3:17 pm
 
Forum: Molecular Biology
Topic: Can you recommend a vector?
Replies: 0
Views: 1417

Re: Experimental evidence for evolution

... that some complex mutation, or multiple mutations, activated cryptic genes that jointly expressed a citrate transporter, although the genes were ... a gene, citT, encoding a citrate– succinate antiporter. High-level constitutive expression of this gene on a multicopy plasmid allows aerobic ...

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by robsabba
Wed Jun 23, 2010 2:25 pm
 
Forum: Evolution
Topic: Experimental evidence for evolution
Replies: 103
Views: 175894

Re: Experimental evidence for evolution

... that some complex mutation, or multiple mutations, activated cryptic genes that jointly expressed a citrate transporter, although the genes were ... a gene, citT, encoding a citrate– succinate antiporter. High-level constitutive expression of this gene on a multicopy plasmid allows aerobic ...

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by jevg
Tue Jun 22, 2010 9:58 pm
 
Forum: Evolution
Topic: Experimental evidence for evolution
Replies: 103
Views: 175894
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