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Conserved sequence

Conserved sequence

(Science: molecular biology) a base sequence in a dna molecule (or an amino acid sequence in a protein) that has remained essentially unchanged throughout evolution.

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I have got some BIG issues! forgive the long post

... RHD and RHCE genes, each, contain 10 exons and span ~75 kb DNA sequence. Complex formation with the product of another single copy gene ... an extended haplotype O. The extended haplotypes could be evolutionary conserved and are often refereed to as ancestral haplotypes. The allelic ...

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by saddy51
Sun Jan 04, 2015 10:39 am
Forum: Genetics
Topic: I have got some BIG issues! forgive the long post
Replies: 1
Views: 1948

Living or not? (viruses,viroids and prions).

... that could only be distinguished using electron microscopy. They also sequenced its entire genome, which turned out to be the largest virus genome ... when did the common ancestor exist? The authors line up a few of the conserved megavirus genes (including those of a more distantly related giant ...

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by Sumanth001
Sun Dec 08, 2013 12:37 pm
Forum: Microbiology
Topic: Living or not? (viruses,viroids and prions).
Replies: 15
Views: 18158

Re: How did endosymbionts coordinate replication?

... So, I suppose, in any eukaryotic cell the mtDNA should be relatively conserved. However, the mutational rate of mtDNA is ten fold higher than that of nuclear DNA. So is the mtDNA sequence conserved among e.g. various mammalian species or the opposite?

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by kk
Tue Feb 26, 2013 8:29 am
Forum: Cell Biology
Topic: How did endosymbionts coordinate replication?
Replies: 14
Views: 9927

Why would the identical amino acids region of certain specie

OK, so you have DNA sequences from related species which are somewhere diverse, somewhere are identical. For example the region coding for active site will be probably conserved, while some loops on surface of the protein will be divergent. Both on DNA and amino ...

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by JackBean
Mon Feb 18, 2013 3:51 pm
Forum: Genetics
Topic: Why would the identical amino acids region of certain specie
Replies: 2
Views: 3661


... he wants is primer for cloning, not for sequencing. Imagine you have sequence ATG GTC ATC GTC TGA GTC and first three amino acids belong to signal ... and bad cholesterol, HDLP, LDLP). I don't know whether they have some conserved motif. 2) primers should be 20-25 bp long. That should be sufficient ...

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by coppcw08
Mon Nov 05, 2012 12:27 am
Forum: Molecular Biology
Topic: Sequencing question/primer design
Replies: 4
Views: 3844
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