Conjugated

... Science, you got that one wrong. That peptide was developed and added by my wife, Hong Moulton of AVI BioPharma. Qi Long Lu received the peptide-conjugated Morpholino from Hong and conducted his excellent studies in mice: Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, ...

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... Global Therapeutics, a Cook Medical company, has initiated the world's first clinical trial of a drug eluting stent that uses a PPMO (peptide-conjugated morpholino phosphorodiamidate oligomer)-based RNA therapeutic agent aimed at silencing C-MYC, one of the genes responsible for causing arteries ...

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I expect that AVI BioPharma http://www.avibio.com will start systemic clinical trials of their peptide-conjugated oligos targeting dystrophin for treatment of Duchenne muscular dystrophy within a year. Their trials with bare Morpholinos have been ongoing in London. http://clinicaltrials.gov/ct2/show/NCT00159250 ...

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... genome. Virology. 2008 Sep 8. [Epub ahead of print] Yin H, Moulton HM, Seow Y, Boyd C, Boutilier J, Iverson P, Wood MJ. Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function. Hum Mol Genet. 2008 Sep 10. [Epub ahead ...

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... location of the antibodies differs. Immunofluorescent methods use antibodies labeled with fluorescent moieties (fluorochromes). Usually these are conjugated with a secondary antibody which is used to bind to a primary antibody bound to cellular antigen. The antigen can be outside the cell or inside, ...

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