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Competitive inhibition

Competitive inhibition

(Science: chemistry) inhibitor that occupies the active site of an enzyme or the binding Site of a receptor and prevents the normal substrate or ligand from binding.

at sufficiently high concentration of the normal ligand inhibition is lost: the Km is altered by the competitive inhibitor, but the vmax remains the same.


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Inhibitor

... and measure reaction rate. The results will tell you whether your inhibition is competitive or not (I let you figure out how).

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by canalon
Mon Mar 19, 2012 1:35 am
 
Forum: Molecular Biology
Topic: Inhibitor
Replies: 2
Views: 1119

how to choose your PI3K inhibitors

... target the ATP-binding pocket. Wortmannin is the first one. LY294002,a competitive PI3K inhibitor,appear in 1994.LY294002 is ATP competitive. LY294002 ... binding pocket. Then IC87114 is discovered , has an IC50 of 100 nM for inhibition of p110-δ. TG100–115 which are not chemically derived from ...

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by kenzhang
Fri Apr 22, 2011 10:43 am
 
Forum: Cell Biology
Topic: how to choose your PI3K inhibitors
Replies: 0
Views: 2106

Re: Competitive/Non competitive inhibitors

... won’t be able to characterize them actual well, but you may still be able to see that if you adapt the extracts in the aforementioned way, you get inhibition of anylase activity, or that altered types of seeds, etc. able the aforementioned way accord altered degrees of inhibition. If you just appear ...

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by rsreign
Thu Jun 25, 2009 10:45 am
 
Forum: Molecular Biology
Topic: Competitive/Non competitive inhibitors
Replies: 5
Views: 12858

Re: Caffeine Coursework

... mechanism of action). Therefore, caffeine acts as a competitive inhibitor. Adenosine is found in every part of the body, because ... prolonged mental activity, and that the effects may be mediated both by inhibition of wake-promoting neurons via A1 receptors, and activation of ...

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by red.ninja13
Sun Mar 22, 2009 7:39 pm
 
Forum: Human Biology
Topic: Caffeine Coursework
Replies: 3
Views: 7406

Michaelis-Menton competitive inhibition derivation

Hi all, Does anyone one know where online I could locate a nice clean derivation for MM with competive inhibition? Thanks, Kim

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by KimNu
Fri Oct 17, 2008 4:43 pm
 
Forum: Cell Biology
Topic: Michaelis-Menton competitive inhibition derivation
Replies: 0
Views: 1706
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