Clonorchiasis is a disease caused by the infestation of the Oriental liver fluke, Clonorchis sinensis. The Oriental liver fluke is a trematode species that inhabits the liver, gall bladder, and the common bile duct. This parasitic worm feeds on the bile of the definitive host, such as humans. It may be acquired by ingestion of raw, smoked, or undercooked fish.
Clonorchiasis may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. It may also increase the risk to the development of cholangiocarcinoma.
The common symptoms of clonorchiasis include jaundice, liver tenderness and enlargement, nausea, diarrhea, vomiting, abdominal pain, loss of appetite, and anisakiasis. These symptoms are similar to those with Opisthorchis viverrini and Opisthorchis felineus infestations. Thus, the disease with the above symptoms caused by the infestation with Clonorchis sinensis or with either of the other two species may also be called clonorchiasis.1
1 King, S. & Scholz, T. (2001). "Trematodes of the family Opisthorchiidae: A minireview". The Korean Journal of Parasitology. 39 (3): 209–21.