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Chaperonins

Chaperonins

a class of sequence-related molecular chaperones found in bacteria, mitochondria, and plastids. Chaperonins are abundant constitutive proteins that increase in amount after stresses such as heat shock, bacterial infection of macrophages, and an increase in the cellular content of unfolded proteins. Bacterial chaperonins are major immunogens in human bacterial infections because of their accumulation during the stress of infection. Two members of this class of chaperones are chaperonin 10 and chaperonin 60.


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Question about chaperonins and disease

Do they really fold without outside disturbances? I would consider the chaperonins to be an outside disturbance. I thought chaperonins help the protein to fold in a way that is condusive to its ultimate function. That yes, it does keep out other influences, ...

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by kolean
Wed Sep 23, 2009 12:59 pm
 
Forum: Molecular Biology
Topic: Question about chaperonins and disease
Replies: 5
Views: 3014

Question about chaperonins and disease

What do chaperonins have to do with health like mad cow disease proteins called prions? I seriously have no idea. I know chaperonins allow polypeptides to fold without outside disturbances but that's as far as I can get.

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by banaji727
Wed Sep 23, 2009 8:52 am
 
Forum: Molecular Biology
Topic: Question about chaperonins and disease
Replies: 5
Views: 3014

Re: Re:

... statement, that is very wrong. Creative errors are common. Just see simple mutations giving rise to antibiotic resistance. Gene duplications, chaperonins and other mechanism allow the accumulation of mutations without effects, until an event disturb the balance. And generally bad mutations ...

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by canalon
Tue Sep 23, 2008 4:37 pm
 
Forum: Evolution
Topic: Problems with Evolution !
Replies: 33
Views: 23342

HELP Failing Biology

There's also chaperonins etc other folding factors

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by mith
Sun Dec 02, 2007 8:19 pm
 
Forum: Genetics
Topic: HELP Failing Biology
Replies: 5
Views: 3320

Theoretical biologists developing a protein folding theory?

... folding of protein happens in 3 ways, (1) it folds by itself, (2) helped by proteins named chaperones, and (3) helped by a large dome-like protein chaperonins. for the no.1, it can fold to a proper structure sometimes because of series of actions happened after translation, called post-translational ...

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by victor
Tue Jul 17, 2007 4:14 am
 
Forum: General Discussion
Topic: Theoretical biologists developing a protein folding theory?
Replies: 5
Views: 2494
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