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Chaperone

Chaperone

(Science: cell biology) cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein.


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Re: Any ideas for vaccine development or anti-viral drugs???

... 2014 Jul 11. Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone ...

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by jonmoulton
Mon Sep 15, 2014 3:04 pm
 
Forum: Cell Biology
Topic: Any ideas for vaccine development or anti-viral drugs???
Replies: 2
Views: 479

Re: Hsp70 vs. BiP

sorry, I just sometimes have a hard time trusting wiki... I like to get a 2nd opinion. BiP is a chaperone that normally binds Ire1p, during the unfolded protein response, however, it dissociates form Ire1p so that it can assist in protein folding... I think it's a heat ...

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by ryanbarnhill
Mon Mar 01, 2010 3:38 pm
 
Forum: Cell Biology
Topic: Hsp70 vs. BiP
Replies: 4
Views: 2944

Re: Chaperone proteins

I think chaparons bind to hydrophobic parts of proteins, no matter the aa-sequence, folding it correctly. I'm not too sure thought.

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by Swede
Wed Feb 24, 2010 8:12 pm
 
Forum: Cell Biology
Topic: Chaperone proteins
Replies: 4
Views: 2698

Chaperone proteins

Can anyone tell what portion of a protein chaperones bind?

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by ryanbarnhill
Wed Feb 24, 2010 6:50 pm
 
Forum: Cell Biology
Topic: Chaperone proteins
Replies: 4
Views: 2698

Re: Generation of DNA nucleotides

... this with a model organism, or perhaps just dividing cells in culture (though there is a difference between in vivo and in vitro ). There are chaperone proteins that help in the proper folding of proteins as they are being translated. RNA also has some help in folding into the proper hairpin ...

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by kolean
Wed Jan 06, 2010 2:05 pm
 
Forum: Molecular Biology
Topic: Generation of DNA nucleotides
Replies: 65
Views: 59171
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