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Cgrp

Cgrp --> calcitonin gene-related peptide

(Science: protein) a second product transcribed from the calcitonin gene. Calcitonin gene related peptide is found in a number of tissues including nervous Tissue. It is a vasodilator that may participate in the cutaneous triple response.

It is a neuropeptide of 37 amino acids with structural homology to salmon calcitonin. Co-localises with substance p in neurons. It occurs as a result of alternative processing of mrna from the calcitonin gene.

The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

Intracerebral administration leads to a rise in noradrenergic sympathetic outflow, a rise in blood pressure and a fall in gastric secretion.

Acronym: cgrp


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The Fiber Disease

... of the nerves also leads to the release of “proinflammatory” substances from peripheral nerve endings. The Calcitonin-gene-related peptide (CGRP) and substance P (SP) are two neuropeptides that are present in C- and A-fibre afferents and that are released upon stimulation of peripheral nerve ...

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by Skytroll
Sun Sep 10, 2006 7:16 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560039

The Fiber Disease

... of the nerves also leads to the release of “proinflammatory” substances from peripheral nerve endings. The Calcitonin-gene-related peptide (CGRP) and substance P (SP) are two neuropeptides that are present in C- and A-fibre afferents and that are released upon stimulation of peripheral nerve ...

See entire post
by Skytroll
Sun Sep 03, 2006 6:37 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5560039


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