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Centromere

Definition

noun, plural: centromeres

(1) The constricted region joining the two sister chromatids that make up an X-shaped chromosome.

(2) The site where kinetochore is formed.


Supplement

Centromere is important particularly during mitosis. Aside from being the region where chromatids are held and kinetochore is formed, it also serves as the point of attachment for spindle fibers when the spindle fibers are pulling the chromosomes toward the centrioles (situated on opposite poles in a cell) prior to cytokinesis.

When the centromere is not functioning properly, the chromatids do not align and separate properly, thus, resulting in the wrong number of chromosomes in the daughter cells, and conditions such as Down syndrome.


Word origin: From Latin centrum and Greek kentron + from Greek meros, part.
Related forms: centromeric (adjective).

Compare: kinetochore.
See also: chromatid.


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Re: Mitosis and meiosis!

... the equatorial line while metaphase in mitosis not. In Anaphase I, the homologous chromosomes are separated while sister chromatids are split at centromere in Anaphase of mitosis. You may get more info about meiosis at http://www.ask4biology.com/cell-biology/meiosis/

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by mavis
Wed Jan 30, 2013 9:00 am
 
Forum: Cell Biology
Topic: Mitosis and meiosis!
Replies: 3
Views: 4183

How dominance works at the DNA/RNA/protein

... parent. ... No. Chromatids are present ONLY during cell division when each chromosome is duplicated and 2 sister chromatids are joined at the centromere. They would be identical to each other IF there was no recombination... The rest of your reasoning is faulty at best. I’ll try to explain ...

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by Cat
Fri Oct 05, 2012 1:15 am
 
Forum: Genetics
Topic: How dominance works at the DNA/RNA/protein
Replies: 10
Views: 7363

Centromeres in a resting nucleus

... take a look at this statement: Centromeres appear as constitutive heterochromatin in a resting nucleus. Is that true? Does that mean that the centromere sequences have no function in non-dividing cells? So, the centromeres must have sequences which only help them to bind to microtubules via ...

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by Adz795
Sun Dec 04, 2011 9:55 am
 
Forum: Cell Biology
Topic: Centromeres in a resting nucleus
Replies: 3
Views: 1726

Re: Some Questions

Centromere --> Place where sister chromatids are held in contact Ethical issue --> Embryonic stem cells Organisms with a definite nucleus --> Eukaryotes

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by cw11
Tue Nov 29, 2011 2:26 am
 
Forum: Cell Biology
Topic: Some Questions
Replies: 3
Views: 1941

Some Questions

... dearly appreciate if they were to be answered. Growing Cells in a test tube is called? I think it is growth of bacteria, not sure. What is the centromere? Inside the nucleus? What is an error in cell division called? Name an ethical issue in modern biology? Cancer? Really stuck on this one. ...

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by IwannaLearn
Fri Nov 18, 2011 7:15 pm
 
Forum: Cell Biology
Topic: Some Questions
Replies: 3
Views: 1941
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