Dictionary » C » Centromere



noun, plural: centromeres

(1) The constricted region joining the two sister chromatids that make up an X-shaped chromosome.

(2) The site where kinetochore is formed.


Centromere is important particularly during mitosis. Aside from being the region where chromatids are held and kinetochore is formed, it also serves as the point of attachment for spindle fibers when the spindle fibers are pulling the chromosomes toward the centrioles (situated on opposite poles in a cell) prior to cytokinesis.

When the centromere is not functioning properly, the chromatids do not align and separate properly, thus, resulting in the wrong number of chromosomes in the daughter cells, and conditions such as Down syndrome.

Word origin: From Latin centrum and Greek kentron + from Greek meros, part.
Related forms: centromeric (adjective).

Compare: kinetochore.
See also: chromatid.

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Re: Chromatin

... of paternal origin, plus the maternally-contributed mitochondrial chromosome (which I'll ignore for the rest of this post). Counting chromosomal centromeres, there are 46 centromeres total. After replication there are still 46 centromeres, but the mass of DNA and number of chromatids have doubled ...

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by jonmoulton
Thu Sep 04, 2014 3:04 pm
Forum: Genetics
Topic: Chromatin
Replies: 2
Views: 4226

Re: Mitosis and meiosis!

... the equatorial line while metaphase in mitosis not. In Anaphase I, the homologous chromosomes are separated while sister chromatids are split at centromere in Anaphase of mitosis. You may get more info about meiosis at http://www.ask4biology.com/cell-biology/meiosis/

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by mavis
Wed Jan 30, 2013 9:00 am
Forum: Cell Biology
Topic: Mitosis and meiosis!
Replies: 3
Views: 5061

How dominance works at the DNA/RNA/protein

... parent. ... No. Chromatids are present ONLY during cell division when each chromosome is duplicated and 2 sister chromatids are joined at the centromere. They would be identical to each other IF there was no recombination... The rest of your reasoning is faulty at best. I’ll try to explain ...

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by Cat
Fri Oct 05, 2012 1:15 am
Forum: Genetics
Topic: How dominance works at the DNA/RNA/protein
Replies: 10
Views: 9794

Centromeres in a resting nucleus

... take a look at this statement: Centromeres appear as constitutive heterochromatin in a resting nucleus. Is that true? Does that mean that the centromere sequences have no function in non-dividing cells? So, the centromeres must have sequences which only help them to bind to microtubules via ...

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by Adz795
Sun Dec 04, 2011 9:55 am
Forum: Cell Biology
Topic: Centromeres in a resting nucleus
Replies: 3
Views: 2059

Re: Some Questions

Centromere --> Place where sister chromatids are held in contact Ethical issue --> Embryonic stem cells Organisms with a definite nucleus --> Eukaryotes

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by cw11
Tue Nov 29, 2011 2:26 am
Forum: Cell Biology
Topic: Some Questions
Replies: 3
Views: 2303
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