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Cd4

Definition

noun

A 55-kD glycoprotein that serves as differentiation antigen found on the surface of T lymphocytes and macrophages.


Supplement

The CD in CD4 is an abbreviation for cluster of differentiation. It belongs to the immunoglobulin supergene family. The presence of CD4 characterizes the helper/inducer cell. It also serves as HIV receptors where the virus binds directly with its envelope protein gp120.


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Bio Research Paper Writing

... target point for infectious agents not limited to the viral infections, studies have shown that mouse thymus have autoreactive thymus derived CD4 and CD8 T-cells capable of some defense function while still immature which correlates with the increased migratory cytokines that help mobilize ...

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by NathanielZhu
Thu Apr 04, 2013 2:25 am
 
Forum: General Discussion
Topic: Bio Research Paper Writing
Replies: 1
Views: 11972

Re: Proliferation assay

... cells) and then staining with CD3. I sort the cells and then stimulate them for proliferation with PHA(2microlitre). I also stain the cells with CD4 and CD8 on the day of analysis. I add PI jus before running the cells on the flow cytometer to discriminate for live vs dead cells.I am worried ...

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by hemhaspri
Wed Jun 13, 2012 6:29 am
 
Forum: Cell Biology
Topic: Proliferation assay
Replies: 7
Views: 10894

Re: Difference between T-Cell and Phagocyte?

... magnify the immune response. I am not entirely sure, but I think other B cells have to have the same antigen presented, and it binds to them via a CD4 molecule (remember a helper T cell has several CD4 molecules). Activation of B cells via cytokines from helper T cells cause the proliferation of ...

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by aptitude
Sun Sep 11, 2011 7:27 am
 
Forum: Physiology
Topic: Difference between T-Cell and Phagocyte?
Replies: 10
Views: 49740

Immunology: Th1/Th2 vs cellular/humoral responses

This is where the difference between the two distinctions becomes unclear to me. CD4+ T cells that help CD8+ T cells are referred to as Th1 cells, correct? CD4+ T cells that help B cells are referred to as Th2 cells.. (links removed ~ Admin)

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by Aiyaya
Wed Aug 31, 2011 2:05 am
 
Forum: Cell Biology
Topic: Immunology: Th1/Th2 vs cellular/humoral responses
Replies: 10
Views: 42884

Re: Immunology: Th1/Th2 vs cellular/humoral responses

... detailed functional analysis in the future. My point, however, is that I would like to respectfully disagree with biohazard's assessment that CD4+ T cells are not direct effectors in the way a classical CD8+ T cell is thought to be. This was certainly the long-held theory, but not so recent ...

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by biohazard
Thu Aug 25, 2011 9:52 am
 
Forum: Cell Biology
Topic: Immunology: Th1/Th2 vs cellular/humoral responses
Replies: 10
Views: 42884
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