A 55-kD glycoprotein that serves as differentiation antigen found on the surface of T lymphocytes and macrophages.


The CD in CD4 is an abbreviation for cluster of differentiation. It belongs to the immunoglobulin supergene family. The presence of CD4 characterizes the helper/inducer cell. It also serves as HIV receptors where the virus binds directly with its envelope protein gp120.

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