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Cd3

Cd3

(Science: immunology) a complex of at least five membrane-bound polypeptides in mature t-lymphocytes that are non-covalently associated with one another and with the t-cell receptor (receptors, antigen, t-cell). The cd3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the t-cell receptor, the cd3 complex transduces the activating signals to the cytoplasm of the t-cell. The cd3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the t-cell receptor (receptors, antigen, t-cell, gamma-delta).


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FACS Cells Markers

... cells markers in mouse. I founded some markers, but I'm not sure if they are ok. So can you tell me what do you think about my selection ? LT : CD3 LB : CD19 Neutrophiles (most important cells for me) : Ly6G high and ? Dendritic cells : CD11c high and ? NK : CD49b or CD335 Macrophages : F4/80 ...

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by aureliegineste
Wed Nov 20, 2013 10:26 am
 
Forum: Cell Biology
Topic: FACS Cells Markers
Replies: 0
Views: 626

Re: Proliferation assay

Dear all I do a proliferation assay after pulsing PBMCS with CFSE (5micromol for 2-10million cells) and then staining with CD3. I sort the cells and then stimulate them for proliferation with PHA(2microlitre). I also stain the cells with CD4 and CD8 on the day of analysis. I add PI ...

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by hemhaspri
Wed Jun 13, 2012 6:29 am
 
Forum: Cell Biology
Topic: Proliferation assay
Replies: 7
Views: 10996

Cluster of Differenciation(CD) replacement... Immunology

... designations come from the type of chains that form the T cell receptor (TCR). Majority of the T cells have alpha and beta chains in their TCR. CD3 is the co-receptor of the TCR, and thus both a/b and g/d T cells have CD3 expressed with the TCR - without CD3 the TCR is dysfunctional. CD4 is ...

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by biohazard
Mon May 31, 2010 6:10 am
 
Forum: Molecular Biology
Topic: Cluster of Differenciation(CD) replacement... Immunology
Replies: 6
Views: 6310

Cluster of Differenciation(CD) replacement... Immunology

... idea what i'm talking about, but im really interested in immunology. so if im wrong, i guess i am. you said that both a/b and d/g t-cells present CD3? i thought that d/g t cells presented CD3 and a/b presented CD4?

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by mortonman1
Sat May 29, 2010 4:22 am
 
Forum: Molecular Biology
Topic: Cluster of Differenciation(CD) replacement... Immunology
Replies: 6
Views: 6310

Re:

Ok you answered everything pretty much. but I'm more so wondering if one can move the CD3 protein from a gamma t cell to a Cd4 t cell, and place the CD3 protein on the surface of the CD4 t cell to act as a replacement. This would hopefully make it so that HIV gp120 ...

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by biohazard
Fri May 28, 2010 12:39 pm
 
Forum: Molecular Biology
Topic: Cluster of Differenciation(CD) replacement... Immunology
Replies: 6
Views: 6310
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