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Cd14

Cd14

(Science: immunology) Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (lps) and lps-binding protein.


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Learning tissue culture, specifically moDC generation

... also to see the morphological changes in the monocytes as they mature. If you have an access to a cytometer, use of antibodies for something like CD14, CD83 and CD86 (if I recall correctly) helps to evaluate the degree of maturation of your cells. Disclaimer: the above is written based on what ...

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by biohazard
Fri Feb 03, 2012 2:09 pm
 
Forum: Cell Biology
Topic: Learning tissue culture, specifically moDC generation
Replies: 2
Views: 2225

Antibodies to ID mouse neutrophils and monocytes

... activated cell sorting and in frozen and paraffin sections. - Sa14-2 Sa14-2 is a monoclonal antibody that reacts with the mouse monocyte marker CD14.

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by DoctorStein
Sat Jul 12, 2008 7:35 am
 
Forum: Cell Biology
Topic: Antibodies to ID mouse neutrophils and monocytes
Replies: 7
Views: 6912

thanks LiKim

yes, you are right... that LPS is transferred to CD14 by a lipid transferase LPS-binding protein(LBP). LPS-CD-14 stimulates TLR-4-MD-2 on the cell surface. and this interaction causes oligomerization. Next, it trigger two pathways MyD88 dependent ...

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by konstantin
Sat Nov 25, 2006 9:42 am
 
Forum: Cell Biology
Topic: TLR-4 and downstream stuff does somebody work in this branch
Replies: 10
Views: 4445


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