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Calcineurin

(Science: protein) calmodulin stimulated protein phosphatase (EC 3.1.3.16), the major calmodulin binding protein in brain.

enzymic activity is inhibited by binding of immunophilin ligand complex (immunophilin alone does not bind) and therefore may play a part in the mechanism of action of cyclosporin a and FK506. Thought also to be involved in the control of sperm motility.