Calbindin are originally described as vitamin D-dependent calcium binding proteins that are found in the intestine, brain, kidney, gut and pancreatic islets in mammals. In normal brain calbindin are recognized in medium sized neurons found in the matrix compartment of striatum, globus pallidus and pars reticula of the substantia nigra. The common expressions of calbindin are tailored in patients with progressive supranuclear palsy, striatal degeneration and Huntingdon's disease.
Calbindin are involved in aiding the absorption of calcium from the intestine and its re-absorption from the glomerular filtrate in the renal tubules as well as the deposition of calcium in mineralized tissues wherein two types of calbindin are identified, calbindin D9k and calbindin D28k. An amount of dendritic cells within the light zone of germinal centers are renowned to be positive for calbindin.
The two calcium-binding proteins calbindin and calretinin are reported to express in abundance found in Purkinje cells and other cell types in the cerebellum which are classified in different sub-families since it varies in calcium ion binding sites.
Gene name: calbindin 2 (CALB2)
Protein name: Calretinin (CR)