A classical cadherin superfamily involved in imparting cells ability to adhere in a hemophilic manner and functions a vital role in endothelial cell through the control of cohesion and organization of the intercellular junctions.
Cadherin 5 gene is mapped on chromosome 16q22.1 containing 12 exons in which the first exon is entirely untranslated that span at about 36kb located in a six cadherin cluster at the region on the long arm of chromosome 16 linked in loss of heterozygosity in breast and prostate cancer. Its encoded protein is a calcium dependent glycoprotein that comprised of five extracellular cadherin repeats which functions as an adaptor that activates phosphatidylinositol-3-OH kinase.
Cadherin 5 serves to maintain newly formed vessels and associates with alpha catenin to form linked to the cytoskeleton and function together with KRIT1 to set up and maintain correct endothelial cell polarity and vascular lumen.
Gene name: CDH5
Protein name: Cadherin-5