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Cadherin

Definition

noun, plural: cadherins

Any of a family of cell adhesion molecules that facilitate cell to cell adhesion in a homophilic manner and only when calcium ions are bound to it


Supplement

A cadherin generally has a cytoplasmic domain, a transmembrane domain, and an extracellular domain. The latter is comprised of five subdomains held together by calcium ions. Removal of these ions will result in the collapse of the extracellular domain, thus disrupts homophilic adhesion. This is why cadherins are described as calcium-dependent cell adhesion molecules.

Cadherins are found in various cell types such as in epithelial cells (referred to as E-cadherin), nerve cells (as N-cadherin) and placental cells (as P-cadherin).


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Results from our forum


E-cadherin/calcium

Hi there, I recently did an ELISA with E-cadherin plated onto a 96-well plate then protein then primary anti and then finally secondary antibody. After I had finished it, I thought about the fact that when I plated my protein I had it in PBS ...

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by biology_06er
Fri May 25, 2012 4:37 am
 
Forum: General Discussion
Topic: E-cadherin/calcium
Replies: 1
Views: 875

Green Flourescent Protein & Cadherins

I guess the cells were transformed with cadherin fused with GFP

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by JackBean
Sat Feb 05, 2011 10:06 am
 
Forum: Cell Biology
Topic: Green Flourescent Protein & Cadherins
Replies: 1
Views: 838

Cadherin

... plastic spheres. One batch was made of red plastic, the other of blue plastic. Red plastic spheres were incubated in a solution of purified cadherin IMPs and the blue spheres were incubated with the protein L1. Both cadherin and L1 are normally IMPs but both attached well to the plastic ...

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by forest123
Tue Oct 19, 2010 2:50 pm
 
Forum: Cell Biology
Topic: Cadherin
Replies: 1
Views: 1763

Re: Cadherins

The action of cadherins are, by their nature, calcium-dependent. I have read a lot of articles, but none of them seem to indicate whether the Ca2+ required is intracellular, extracelluar, or a bit of both (I am guessing both). You ...

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by MrMistery
Wed Dec 16, 2009 2:01 am
 
Forum: Cell Biology
Topic: Cadherins
Replies: 2
Views: 2457

Cadherins

The action of cadherins are, by their nature, calcium-dependent. I have read a lot of articles, but none of them seem to indicate whether the Ca2+ required is intracellular, extracelluar, or a bit of both (I am guessing both). My ...

See entire post
by Hodag
Tue Dec 15, 2009 10:34 pm
 
Forum: Cell Biology
Topic: Cadherins
Replies: 2
Views: 2457
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