Dictionary » B » Bromouracil



(Science: chemical) 5-bromo-2,4(1h,3h)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in dna. It is used mainly as an experimental mutagen, but its deoxyriboside (bromodeoxyuridine) is used to treat neoplasms.

Pharmacological action: antimetabolites, mutagens.

chemical name: 2,4(1H,3H)-Pyrimidinedione, 5-bromo-

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Re: about chargaff's rule

... but on the other strand, because a C was bound, the A is replaced by a G. This is complex chemistry though. The same can happen when the mutagen 5-bromouracil is precent. Normally U will bind A, but 5-bromouracil i=can tautomerize to a so-called enol form which has a higher frequence. It binds ...

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by sdekivit
Tue Aug 15, 2006 3:19 pm
Forum: Molecular Biology
Topic: Chargaff's bases
Replies: 15
Views: 6264

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